Continuous intravenous pentagastrin as a stimulant of maximal gastric acid secretion.
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چکیده
منابع مشابه
Continuous intravenous pentagastrin as a stimulant of maximal gastric acid secretion.
The synthetic gastrin-like pentapeptide (ICI 50, 123) may soon replace histamine as the standard stimulant of gastric secretion. As a diagnostic aid and for routine estimations a simple intramuscular test (Johnston and Jepson, 1967) may suffice. For research procedures, however, the rapid metabolism of the stimulant and the ability to produce a plateau of secretion give the intravenous infusion...
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Does gastrin stimulate gastric acid secretion by direct action on oxyntic cells, by releasing histamine, or by being potentiated by histamine? Previous studies in the mouse pointed to gastrin-regulated histamine release. Guinea pig and rat are well known to vary in their sensitivity to histamine. Therefore, the effects of histamine and pentagastrin were compared quantitatively on isolated, lume...
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As bstract. The reason for increased maximal acid secretory capacity in some patients with duodenal ulcer is uncertain. We postulated that chronically increased cephalic-vagal stimulation may be a cause of increased maximal acid output. To study this, we prepared six male, mongrel dogs with a vagally innervated gastric fistula, a vagally denervated fundic (Heidenhain) pouch, and a cervical esop...
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Single intravenous doses of 10, 20, 40, and 80 mg and repeated once daily intravenous doses of 10 and 20 mg omeprazole induced a powerful and long lasting inhibition of pentagastrin stimulated gastric acid secretion (PAO) in healthy male volunteers. Single intravenous doses of 10, 20, 40, and 80 mg omeprazole inhibited PAO by 30% (p less than 0.01), 45% (p less than 0.01), 61% (p less than 0.01...
متن کاملEffect of continuous infusion of pentagastrin on lower esophageal sphincter pressure and gastric acid secretion in normal subjects.
Bolus injections of gastrin or pentagastrin (PG) cause a marked elevation in lower esophageal sphincter pressure (LESP), and it has been suggested that serum gastrin concentration is the main physiological and pathophysiological regulator of LESP. We evaluated this hypothesis by measuring LESP and gastric acid secretion simultaneously in normal subjects during continuous infusion of PG (0.004-1...
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ژورنال
عنوان ژورنال: Gut
سال: 1969
ISSN: 0017-5749
DOI: 10.1136/gut.10.1.34